STRUCTURAL CHARACTERISTICS OF OSTEOPONTIN FOR CALCIUM OXALATE CRYSTAL
نویسندگان
چکیده
منابع مشابه
Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules.
Calcium nephrolithiasis is the most common form of renal stone disease, with calcium oxalate (CaOx) being the predominant constituent of renal stones. Current in vitro evidence implicates osteopontin (OPN) as one of several macromolecular inhibitors of urinary crystallization with potentially important actions at several stages of CaOx crystal formation and retention. To determine the importanc...
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Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease therapies and can help define general strategies for synthesizing biologically ins...
متن کاملUrinary calcium oxalate crystal growth inhibitors.
Calcium stones occur because renal tubular fluid and urine are supersaturated with respect to calcium oxalate and phosphate. The process of stone formation includes crystal nucleation, growth, aggregation, and attachment to renal epithelia. Urine contains macromolecules that modify these processes and may protect against stone formation. Attention has focused especially on inhibitors of crystal...
متن کاملNormal calcium oxalate crystal growth inhibition in severe calcium oxalate nephrolithiasis.
Urine from mammalian kidneys is regularly supersaturated with respect to calcium oxalate monohydrate, the most common solid phase in human nephrolithiasis, and also inhibits the nucleation, growth, and aggregation of calcium oxalate crystals. Nephrolithiasis is often associated with increased supersaturation, and it is assumed that this increase overbalances the inhibition effects, causing ston...
متن کاملEffect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys.
Hyperoxaluria leads to calcium oxalate (CaOx) crystallization and development of tubulointerstitial lesions in the kidneys. Treatment of hyperoxaluric rats with angiotensin II (Ang II) type I receptor blocker (ARB) reduces lesion formation. Because Ang II mediates osteopontin (OPN) synthesis, which is involved in both macrophage recruitment and CaOx crystallization, it was hypothesized that ARB...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1999
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1989.90.436